HMM Summary Page: TIGR04070

Functionspore photoproduct lyase
Gene SymbolsplB
Trusted Cutoff400.00
Domain Trusted Cutoff400.00
Noise Cutoff350.00
Domain Noise Cutoff350.00
Isology Typeequivalog
EC Number4.1.99.14
HMM Length338
AuthorHaft DH
Entry DateOct 7 2010 4:32PM
Last ModifiedDec 12 2011 10:37PM
CommentDNA damage to bacterial spores from ultraviolet light accumulates in the form of 5-thyminyl-5,6-dihydrothymine, spore photoproduct. The damage is repaired by spore photoproduct lyase, a member of the radical SAM family of enzymes. The score of this model is set to restrict itself to spore-forming members of the Firmicutes, but additional homologs scoring below the trusted cutoff tend to occur in radioresistant organisms (e.g. Kineococcus radiotolerans) and may be functionally equivalent. A related family in the Mycobacterium lineage is described by family TIGR03886, and may or may not be equivalent in function.
ReferencesRN [1] RM PMID:19178276 RT Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct. RA Chandra T, Silver SC, Zilinskas E, Shepard EM, Broderick WE, Broderick JB RL J Am Chem Soc. 2009 Feb 25;131(7):2420-1.