HMM Summary Page: TIGR04069

Functionpeptide maturation system acyl carrier-related protein
Trusted Cutoff70.00
Domain Trusted Cutoff70.00
Noise Cutoff50.00
Domain Noise Cutoff50.00
Isology Typehypoth_equivalog
HMM Length77
AuthorHaft DH
Entry DateOct 7 2010 1:00PM
Last ModifiedJun 9 2011 9:57AM
CommentBoth PSI-BLAST and large numbers of noise-level HMM hits show a relationship between this family and the phosphopantetheine attachment site domain modeled by PF00550. That domain includes acyl carrier proteins (ACP) and features an essentially invariant serine residue that is the attachment site for the phosphopantetheine prosthetic group. In this family, the corresponding residue is not Ser and is not conserved. Members are found in genomic contexts associated with a small Cys-rich peptide and a radical SAM protein we predict modifies the peptide.
ReferencesRN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0945: radical SAM maturase bacteriocin system, CLI_3235 type (HMM)