HMM Summary Page: TIGR04060

Functionformate transporter FocA
Gene SymbolfocA
Trusted Cutoff290.10
Domain Trusted Cutoff290.10
Noise Cutoff289.90
Domain Noise Cutoff289.90
Isology Typeequivalog
HMM Length268
AuthorHaft DH
Entry DateAug 26 2010 12:46PM
Last ModifiedFeb 14 2011 3:27PM
CommentFocA (formate channel A) forms a pentameric formate-selective channel through the plasma membrane. The focA gene is largely restricted to Proteobacteria and occurs adjacent to genes for pyruvate formate lyase (PFL) and the PFL activase, a radical SAM protein. FocA is homologous to a nitrite transport protein, NirC.
ReferencesRN [1] RM PMID:19940917 RT Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel. RA Wang Y, Huang Y, Wang J, Cheng C, Huang W, Lu P, Xu YN, Wang P, Yan N, Shi Y RL Nature. 2009 Nov 26;462(7272):467-72.