HMM Summary Page: TIGR04054

Functionputative heme d1 biosynthesis radical SAM protein NirJ1
Gene SymbolnirJ1
Trusted Cutoff650.00
Domain Trusted Cutoff650.00
Noise Cutoff600.00
Domain Noise Cutoff600.00
Isology Typeequivalog
HMM Length387
AuthorHaft DH
Entry DateJul 28 2010 10:22AM
Last ModifiedJun 30 2014 10:18AM
CommentMembers of this radical SAM protein subfamily, designated NirJ1, occur in genomic contexts with a paralog NirJ2 and with other nitrite reductase operon genes associated with heme d1 biosynthesis, as in Heliobacillus mobilis and Heliophilum fasciatum. NirJ1 is presumed by bioinformatics analysis (Xiong, et al.) to be a heme d1 biosynthesis protein by context, perhaps involved in conversions of acetate groups to methyl groups in conversion from uroporphyrinogen III. A very closely related protein, involved in alternative heme b biosynthesis, occurs in Desulfovibrio and in methanogens.
ReferencesRN [1] RM PMID:17906152 RT Insight into the haem d1 biosynthesis pathway in heliobacteria through bioinformatics analysis. RA Xiong J, Bauer CE, Pancholy A RL Microbiology. 2007 Oct;153(Pt 10):3548-62.