HMM Summary Page: TIGR04020

Functionnatural product biosynthesis luciferase-like monooxygenase domain
Trusted Cutoff244.45
Domain Trusted Cutoff244.45
Noise Cutoff158.60
Domain Noise Cutoff158.60
Isology Typesubfamily_domain
EC Number1.-.-.-
HMM Length341
AuthorHaft DH
Entry DateJun 15 2010 11:46AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a subfamily within the bacterial luciferase-like monooxygenase (LLM) family that regularly occurs within large non-ribosomal protein synthases/polyketide synthases, but also as small proteins. The LLM family includes members that bind either FMN or F420, and FMN is more likely in this case because many members are from species that lack F420 biosynthesis capability. An example member is the MupA protein of mupirocin biosynthesis in Pseudomonas fluorescens NCIMB 10586.
ReferencesRN [1] RM PMID:11495990 RT Quorum-sensing-dependent regulation of biosynthesis of the polyketide antibiotic mupirocin in Pseudomonas fluorescens NCIMB 10586. RA El-Sayed AK, Hothersall J, Thomas CM RL Microbiology. 2001 Aug;147(Pt 8):2127-39.