HMM Summary Page: TIGR03991

FunctionUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase
Gene SymbolglmU
Trusted Cutoff225.30
Domain Trusted Cutoff225.30
Noise Cutoff223.50
Domain Noise Cutoff223.50
Isology Typehypoth_equivalog
EC Number2.7.7.23
HMM Length394
AuthorSelengut J
Entry DateApr 21 2010 1:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe MJ_1101 protein from Methanococcus jannaschii has been characterized as the GlmU enzyme catalyzing the final two steps of UDP-GlcNAc biosynthesis [1]. Homologs of this enzyme are identified in a number of bacterial organisms and modeled here. A number of these are observed in proximity to the GlmS and GlmM genes, and phylogenetic profiling by PPP [2] identifies the LEPBI_I0518 gene in Leptospira biflexa as a likely Glm-system candidate. Multiple sequence alignments of these bacterial homologs with their archaeal counterparts reveals significant structural differences, necessitating the construction of separate models.
ReferencesRN [1] RM PMID:18263721 RT Acetamido sugar biosynthesis in the Euryarchaea. RA Namboori SC, Graham DE RL J Bacteriol. 2008 Apr;190(8):2987-96. Epub 2008 Feb 8. RN [2] RM PMID:16930487 RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic. RA Haft DH, Paulsen IT, Ward N, Selengut JD RL BMC Biol. 2006 Aug 24;4:29.
Genome PropertyGenProp0750: UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate (HMM)