| Accession | TIGR03991 |
| Name | alt_bact_glmU |
| Function | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase |
| Gene Symbol | glmU |
| Trusted Cutoff | 225.30 |
| Domain Trusted Cutoff | 225.30 |
| Noise Cutoff | 223.50 |
| Domain Noise Cutoff | 223.50 |
| Isology Type | hypoth_equivalog |
| EC Number | 2.7.7.23 2.3.1.157 |
| HMM Length | 394 |
| Author | Selengut J |
| Entry Date | Apr 21 2010 1:31PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The MJ_1101 protein from Methanococcus jannaschii has been characterized as the GlmU enzyme catalyzing the final two steps of UDP-GlcNAc biosynthesis [1]. Homologs of this enzyme are identified in a number of bacterial organisms and modeled here. A number of these are observed in proximity to the GlmS and GlmM genes, and phylogenetic profiling by PPP [2] identifies the LEPBI_I0518 gene in Leptospira biflexa as a likely Glm-system candidate. Multiple sequence alignments of these bacterial homologs with their archaeal counterparts reveals significant structural differences, necessitating the construction of separate models. |
| References | RN [1]
RM PMID:18263721
RT Acetamido sugar biosynthesis in the Euryarchaea.
RA Namboori SC, Graham DE
RL J Bacteriol. 2008 Apr;190(8):2987-96. Epub 2008 Feb 8.
RN [2]
RM PMID:16930487
RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.
RA Haft DH, Paulsen IT, Ward N, Selengut JD
RL BMC Biol. 2006 Aug 24;4:29. |
| Genome Property | GenProp0750: UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate (HMM) |
