HMM Summary Page: TIGR03990

Functionphosphoglucosamine mutase
Gene SymbolglmM
Trusted Cutoff439.00
Domain Trusted Cutoff439.00
Noise Cutoff400.30
Domain Noise Cutoff400.30
Isology Typeequivalog
EC Number5.4.2.10
HMM Length444
AuthorSelengut J
Entry DateApr 20 2010 11:48AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe MMP1680 protein from Methanococcus maripaludis has been characterized as the archaeal protein responsible for the second step of UDP-GlcNAc biosynthesis [1]. This GlmM protein catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. The first-characterized bacterial GlmM protein is modeled by TIGR01455. These two families are members of the larger phosphoglucomutase/phosphomannomutase family (characterized by three domains: PF02878, PF02879 and PF02880), but are not nearest neighbors to each other. This model also includes a number of sequences from non-archaea in the Bacteroides, Chlorobi, Chloroflexi, Planctomycetes and Spirochaetes lineages. Evidence supporting their inclusion in this equivalog as having the same activity comes from genomic context and phylogenetic profiling. A large number of these organisms are known to produce exo-polysaccharide and yet only appeared to contain the GlmS enzyme of the GlmSMU pathway for UDP-GlcNAc biosynthesis (GenProp0750). In some organisms including Leptospira, this archaeal GlmM is found adjacent to the GlmS as well as a putative GlmU non-orthologous homolog. Phylogenetic profiling of the GlmS-only pattern using PPP [2] identifies members of this archaeal GlmM family as the highest-scoring result.
ReferencesRN [1] RM PMID:18263721 RT Acetamido sugar biosynthesis in the Euryarchaea. RA Namboori SC, Graham DE RL J Bacteriol. 2008 Apr;190(8):2987-96. Epub 2008 Feb 8. RN [2] RM PMID:16930487 RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic. RA Haft DH, Paulsen IT, Ward N, Selengut JD RL BMC Biol. 2006 Aug 24;4:29.
Genome PropertyGenProp0750: UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate (HMM)