HMM Summary Page: TIGR03973

Functionsix-cysteine peptide SCIFF
Gene SymbolscfA
Trusted Cutoff50.00
Domain Trusted Cutoff50.00
Noise Cutoff35.00
Domain Noise Cutoff35.00
Isology Typehypoth_equivalog
HMM Length43
AuthorHaft DH
Entry DateMar 25 2010 12:30PM
Last ModifiedJul 5 2011 12:33PM
CommentMembers of this protein family are essentially universal in the class Clostidia and therefore highly abundant in the human gut microbiome. This short peptide is designated SCIFF, for Six Cysteines in Forty-Five residues. It is a presumed ribosomal natural product precursor, always found associated with a yet-uncharacterized radical SAM protein, family TIGR03974, that resembles other peptide modification radical SAM enzymes and is designated SCIFF radical SAM maturase.
ReferencesRN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational mo dification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0919: SCIFF/radical SAM Clostridial gene pair (HMM)