HMM Summary Page: TIGR03972

Functionwyosine biosynthesis protein TYW1
Gene Symboltwy1
Trusted Cutoff317.95
Domain Trusted Cutoff317.95
Noise Cutoff315.95
Domain Noise Cutoff315.95
Isology Typeequivalog
HMM Length297
AuthorHaft DH
Entry DateMar 24 2010 4:22PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the archaeal protein TWY1, a radical SAM protein that catalyzes the second step in creating the wye-bases, wyosine and derivatives such as wybutosine, for tRNA base modification.
ReferencesRN [1] RM PMID:17881823 RT Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis. RA Goto-Ito S, Ishii R, Ito T, Shibata R, Fusatomi E, Sekine SI, Bessho Y, Yokoyama S RL Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1059-68. RN [2] RM PMID:17727881 RT Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA. RA Suzuki Y, Noma A, Suzuki T, Senda M, Senda T, Ishitani R, Nureki O RL J Mol Biol. 2007 Oct 5;372(5):1204-14.