HMM Summary Page: TIGR03966

Functionheme/flavin dehydrogenase, mycofactocin system
Gene SymbolmftD
Trusted Cutoff470.85
Domain Trusted Cutoff470.85
Noise Cutoff470.65
Domain Noise Cutoff470.65
Isology Typehypoth_equivalog
EC Number1.-.-.-
HMM Length385
AuthorHaft DH
Entry DateMar 22 2010 11:20AM
Last ModifiedFeb 20 2011 5:52PM
CommentMembers of this protein family possess an N-terminal heme-binding domain and C-terminal flavodehydrogenase domain, and share homology to yeast flavocytochrome b2, to E. coli L-lactate dehydrogenase [cytochrome], to (S)-mandelate dehydrogenase, etc. This enzyme appears only in the context of the mycofactocin system. Interestingly, it is absent from the four species detected so far with mycofactocin but without an F420 biosynthesis system.
ReferencesRN [1] RM PMID:21223593 RT Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners. RA Haft DH RL BMC Genomics. 2011 Jan 11;12(1):21.
Genome PropertyGenProp0917: mycofactocin system (HMM)