| Accession | TIGR03958 |
| Name | monoFe_hyd_HmdC |
| Function | 5,10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdC |
| Gene Symbol | hmdC |
| Trusted Cutoff | 407.00 |
| Domain Trusted Cutoff | 407.00 |
| Noise Cutoff | 406.85 |
| Domain Noise Cutoff | 406.85 |
| Isology Type | equivalog |
| HMM Length | 505 |
| Author | Haft DH |
| Entry Date | Mar 12 2010 11:03AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are HmdC, whose gene regularly occurs in the context of genes for HmdA (5,10-methenyltetrahydromethanopterin hydrogenase) and the radical SAM protein HmdB involved in biosynthesis of the HmdA cofactor. Bioinformatics suggests this protein, a homolog of eukaryotic fibrillarin, may be involved in biosynthesis of the guanylyl pyridinol cofactor in HmdA. |
| References | RN [1]
RM PMID:19897660
RT Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor.
RA McGlynn SE, Boyd ES, Shepard EM, Lange RK, Gerlach R, Broderick JB, Peters JW
RL J Bacteriol. 2010 Jan;192(2):595-8. Epub 2009 Nov 6. |
| Genome Property | GenProp0915: hydrogenase, mono-iron type (HMM) |
