HMM Summary Page: TIGR03957

Function5,10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdB
Gene SymbolhmdB
Trusted Cutoff320.90
Domain Trusted Cutoff320.90
Noise Cutoff132.70
Domain Noise Cutoff132.70
Isology Typeequivalog
HMM Length317
AuthorHaft DH
Entry DateMar 12 2010 10:02AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this archaeal protein family are HmdB, a partially characterized radical SAM protein with an unusual CX5CX2C motif. Its gene flanks the H2-forming methylene-H4-methanopterin dehydrogenase gene hmdA, found in hydrogenotrophic methanogens. HmdB appears to act in in biosynthesis of the novel cofactor of HmdA.
ReferencesRN [1] RM PMID:19897660 RT Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor. RA McGlynn SE, Boyd ES, Shepard EM, Lange RK, Gerlach R, Broderick JB, Peters JW RL J Bacteriol. 2010 Jan;192(2):595-8. Epub 2009 Nov 6.
Genome PropertyGenProp0915: hydrogenase, mono-iron type (HMM)