HMM Summary Page: TIGR03951

Functionsiderophore-iron reductase FhuF
Gene SymbolfhuF
Trusted Cutoff63.85
Domain Trusted Cutoff63.85
Noise Cutoff59.15
Domain Noise Cutoff59.15
Isology Typeequivalog
EC Number1.-.-.-
HMM Length182
AuthorHaft DH
Entry DateMar 8 2010 10:02AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family, including FhuF of E. coli, are siderophore ferric iron reductases that appear to play a role in iron removal from certain hydroxamate-type siderophores, including coprogen, ferrichrome, ferrioxamine B, and aerobactin. Genes occur in regularly in siderophore transport and/or biosynthesis clusters. The C-terminus includes four Cys residues in a C-C-10(X)-C-X-X-C motif that binds a 2Fe-2S cluster. Family TIGR03950 is similar, but especially in the C-terminal region, but likely acts on a different panel of siderophores.
ReferencesRN [1] RM PMID:14756576 RT FhuF, part of a siderophore-reductase system. RA Matzanke BF, Anemuller S, Schunemann V, Trautwein AX, Hantke K RL Biochemistry. 2004 Feb 10;43(5):1386-92.