HMM Summary Page: TIGR03947

Functioncapreomycidine synthase
Gene SymbolvioD
Trusted Cutoff390.90
Domain Trusted Cutoff390.90
Noise Cutoff390.75
Domain Noise Cutoff390.75
Isology Typeequivalog
HMM Length359
AuthorHaft DH
Entry DateFeb 25 2010 2:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the enzyme capreomycidine synthase, which performs the second of two steps in the biosynthesis of 2S,3R-capreomycidine from arginine. Capreomycidine is an unusual amino acid used by non-ribosomal peptide synthases (NRPS) to make the tuberactinomycin class of peptide antibiotic. The best characterized member is VioD from the biosynthetic pathway for viomycin.
ReferencesRN [1] RM PMID:15368581 RT Formation of the nonproteinogenic amino acid 2S,3R-capreomycidine by VioD from the viomycin biosynthesis pathway. RA Yin X, McPhail KL, Kim KJ, Zabriskie TM RL Chembiochem. 2004 Sep 6;5(9):1278-81.
Genome PropertyGenProp0909: capreomycidine biosynthesis (HMM)