| Accession | TIGR03937 |
| Name | PgaC_IcaA |
| Function | poly-beta-1,6 N-acetyl-D-glucosamine synthase |
| Gene Symbol | pgaC |
| Trusted Cutoff | 422.30 |
| Domain Trusted Cutoff | 422.30 |
| Noise Cutoff | 206.80 |
| Domain Noise Cutoff | 206.80 |
| Isology Type | equivalog |
| EC Number | 2.4.1.- |
| HMM Length | 407 |
| Author | Haft DH |
| Entry Date | Feb 11 2010 9:48PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are biofilm-forming enzymes that polymerize N-acetyl-D-glucosamine residues in beta(1,6) linkage. One named members is IcaA (intercellular adhesin protein A), an enzyme that acts (with aid of subunit IcaD) in Polysaccharide Intercellular Adhesin (PIA) biosynthesis in Staphylococcus epidermis). The homologous member in E. coli is designated PgaC. Members are often encoded next to a polysaccharide deacetylase and involved in biofilm formation. Note that chitin, although also made from N-acetylglucosamine, is formed with beta-1,4 linkages. |
| References | RN [1]
RM PMID:15090514
RT The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation.
RA Wang X, Preston JF 3rd, Romeo T
RL J Bacteriol. 2004 May;186(9):2724-34. |
| Genome Property | GenProp0907: poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type (HMM) |
