HMM Summary Page: TIGR03930

FunctionWXG100 family type VII secretion target
Trusted Cutoff44.85
Domain Trusted Cutoff44.85
Noise Cutoff34.45
Domain Noise Cutoff34.45
Isology Typesubfamily
HMM Length90
AuthorHaft DH
Entry DateFeb 4 2010 12:36PM
Last ModifiedSep 11 2011 10:12PM
CommentMembers of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from PF06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.
ReferencesRN [1] RM PMID:18723613 RT ESAT-6-like protein secretion in Bacillus anthracis. RA Garufi G, Butler E, Missiakas D RL J Bacteriol. 2008 Nov;190(21):7004-11. Epub 2008 Aug 22.
Genome PropertyGenProp0904: type VII secretion, Actinobacteria form (HMM-CLUST)
GenProp0905: type VII secretion, Firmicutes form (HMM-CLUST)