HMM Summary Page: TIGR03916

Functionputative DNA modification/repair radical SAM protein
Trusted Cutoff343.50
Domain Trusted Cutoff343.50
Noise Cutoff327.85
Domain Noise Cutoff327.85
Isology Typehypoth_equivalog_domain
HMM Length415
AuthorHaft DH
Entry DateJan 9 2010 4:28PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis uncharacterized protein of about 400 amino acids in length contains a radical SAM protein in the N-terminal half. Members are present in about twenty percent of prokaryotic genomes, always paired with a member of the conserved hypothetical protein TIGR03915. Roughly forty percent of the members of that family exist as fusions with a uracil-DNA glycosylase-like region, TIGR03914. In DNA, uracil results from deamidation of cytosine, forming U/G mismatches that lead to mutation, and so uracil-DNA glycosylase is a DNA repair enzyme. This indirect connection, and the recurring role or radical SAM protein in modification chemistries, suggest that this protein may act in DNA modification, repair, or both.
Genome PropertyGenProp0903: radical SAM/uracil DNA glycosylase system (HMM)