HMM Summary Page: TIGR03915

Functionprobable DNA metabolism protein
Trusted Cutoff112.25
Domain Trusted Cutoff112.25
Noise Cutoff55.80
Domain Noise Cutoff55.80
Isology Typeequivalog_domain
HMM Length243
AuthorHaft DH
Entry DateJan 9 2010 4:16PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a conserved hypothetical protein that almost invariably pairs with an uncharacterized radical SAM protein. The pair occurs in about twenty percent of completed prokaryotic genomes. About forty percent of the members of this family occur as fusion proteins, where the C-terminal domain belongs to the uracil-DNA glycosylase family, a DNA repair family (because uracil in DNA is deamidated cytosine). The linkage by gene clustering and correlated species distribution to a radical SAM protein, and by gene fusion to a DNA repair protein family, suggests a role in DNA modification and/or repair.
Genome PropertyGenProp0903: radical SAM/uracil DNA glycosylase system (HMM)