HMM Summary Page: TIGR03910

Functionpyrrolysine biosynthesis radical SAM protein
Gene SymbolpylB
Trusted Cutoff348.20
Domain Trusted Cutoff348.20
Noise Cutoff347.90
Domain Noise Cutoff347.90
Isology Typeequivalog
HMM Length347
AuthorHaft DH
Entry DateJan 5 2010 3:20PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a radical SAM protein, PylB, that is part of the three-gene cassette sufficient for the biosynthesis of pyrrolysine (the twenty-second amino acid) when expressed heterologously in E. coli. The pyrrolysine next is ligated to its own tRNA and incorporated at special UAG codons.
ReferencesRN [1] RM PMID:17204561 RT A natural genetic code expansion cassette enables transmissible biosynthesis and genetic encoding of pyrrolysine. RA Longstaff DG, Larue RC, Faust JE, Mahapatra A, Zhang L, Green-Church KB, Krzycki JA RL Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):1021-6.
Genome PropertyGenProp0312: pyrrolysine (HMM)