HMM Summary Page: TIGR03897

Functiontype 2 lantibiotic biosynthesis protein LanM
Gene SymbollanM
Trusted Cutoff304.00
Domain Trusted Cutoff304.00
Noise Cutoff287.60
Domain Noise Cutoff287.60
Isology Typesubfamily
HMM Length932
AuthorHaft DH
Entry DateDec 10 2009 9:27AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are known generally as LanM, a multifunctional enzyme of lantibiotic biosynthesis. This catalysis by LanM distinguishes the type 2 lantibiotics, such as mersacidin, cinnamycin, and lichenicidin, from LanBC-produced type 1 lantibiotics such as nisin and subtilin. The N-terminal domain contains regions associated with Ser and Thr dehydration. The C-terminal region contains a PF05147 domain, which catalyzes the formation of the lanthionine bridge.
ReferencesRN [1] RM PMID:19561184 RT Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins. RA Begley M, Cotter PD, Hill C, Ross RP RL Appl Environ Microbiol. 2009 Sep;75(17):5451-60.