HMM Summary Page: TIGR03893

Functiontype 2 lantibiotic, SP_1948 family
Trusted Cutoff32.95
Domain Trusted Cutoff32.95
Noise Cutoff32.65
Domain Noise Cutoff32.65
Isology Typesubfamily
HMM Length61
AuthorHaft DH
Entry DateDec 4 2009 9:39AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM recognizes a number of type 2 lantibiotic-type bacteriocins, related to but distinct from the family that includes lichenicidin and mersacidin. Sequence similarity among members consists largely of a 20-residue block of conserved sequence that covers most of the leader peptide region, absent from the mature lantibiotic. This is followed by a region with characteristic composition for lantibiotic precursor regions, rich in Ser and Thr and including a near-invariant Cys near or at the C-terminus, involved in cyclization. Members of this family typically are shorter than 70 amino acids.
ReferencesRN [1] RM PMID:19477413 RT Dissecting structural and functional diversity of the lantibiotic mersacidin. RA Appleyard AN, Choi S, Read DM, Lightfoot A, Boakes S, Hoffmann A, Chopra I, Bierbaum G, Rudd BA, Dawson MJ, Cortes J RL Chem Biol. 2009 May 29;16(5):490-8.