HMM Summary Page: TIGR03891

Functionthiopeptide-type bacteriocin biosynthesis domain
Trusted Cutoff48.45
Domain Trusted Cutoff48.45
Noise Cutoff38.00
Domain Noise Cutoff38.00
Isology Typesubfamily_domain
HMM Length263
AuthorHaft DH
Entry DateNov 30 2009 10:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis domain occurs within longer proteins that contain lantibiotic dehydratase domains (see PF04737 and PF04738), and as single-domain proteins in bacteriocin biosynthesis genomic contexts. Three named genes in this family, SioK in Streptomyces sioyaensis, TsrD in Streptomyces laurentii, and NosD in Streptomyces actuosus, all occur in regions associated with thiopeptide biosynthesis.
ReferencesRN [1] RM PMID:19246004 RT Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. RA Liao R, Duan L, Lei C, Pan H, Ding Y, Zhang Q, Chen D, Shen B, Yu Y, Liu W RL Chem Biol. 2009 Feb 27;16(2):141-7. RN [2] RM PMID:19265401 RT Thiostrepton biosynthesis: prototype for a new family of bacteriocins. RA Kelly WL, Pan L, Li C RL J Am Chem Soc. 2009 Apr 1;131(12):4327-34.