HMM Summary Page: TIGR03861

Functionalcohol ABC transporter, permease protein
Trusted Cutoff241.35
Domain Trusted Cutoff241.35
Noise Cutoff183.55
Domain Noise Cutoff183.55
Isology Typesubfamily
HMM Length253
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
AuthorHaft DH
Entry DateOct 12 2009 11:19AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family, part of a larger class of efflux-type ABC transport permease proteins, are found exclusively in genomic contexts with pyrroloquinoline-quinone (PQQ) biosynthesis enzymes and/or PQQ-dependent alcohol dehydrogenases, such as the phenylethanol dehydrogenase PedE of Pseudomonas putida U. Members include PedC, an apparent phenylethanol transport protein whose suggested role is efflux to limit intracellular concentrations of toxic metabolites during phenylethanol catalysis.
ReferencesRN [1] RM PMID:18177365 RT Genetic analyses and molecular characterization of the pathways involved in the conversion of 2-phenylethylamine and 2-phenylethanol into phenylacetic acid in Pseudomonas putida U. RA Arias S, Olivera ER, Arcos M, Naharro G, Luengo JM RL Environ Microbiol. 2008 Feb;10(2):413-32. Epub 2007 Dec 27.
Genome PropertyGenProp0895: alcohol ABC transporter, PedABC-type (HMM)