HMM Summary Page: TIGR03852

Functionsucrose phosphorylase
Gene SymbolgtfA
Trusted Cutoff334.40
Domain Trusted Cutoff334.40
Noise Cutoff240.75
Domain Noise Cutoff240.75
Isology Typeequivalog
EC Number2.4.1.7
HMM Length470
AuthorHaft DH
Entry DateOct 6 2009 2:28PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn the forward direction, this enzyme uses phosphate to cleave sucrose into D-fructose + alpha-D-glucose 1-phosphate. Characterized representatives from Streptococcus mutans and Bifidobacterium adolescentis represent well-separated branches of a molecular phylogenetic tree. In S. mutans, the region including this gene has been associated with neighboring transporter genes and multiple sugar metabolism.
ReferencesRN [1] RM PMID:2971020 RT Streptococcus mutans gtfA gene specifies sucrose phosphorylase. RA Russell RR, Mukasa H, Shimamura A, Ferretti JJ RL Infect Immun. 1988 Oct;56(10):2763-5. RN [2] RM PMID:16990265 RT Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion. RA Mirza O, Skov LK, Sprogoe D, van den Broek LA, Beldman G, Kastrup JS, Gajhede M RL J Biol Chem. 2006 Nov 17;281(46):35576-84. Epub 2006 Sep 21.