HMM Summary Page: TIGR03849

Functionphosphosulfolactate synthase
Gene SymbolcomA
Trusted Cutoff331.90
Domain Trusted Cutoff331.90
Noise Cutoff331.70
Domain Noise Cutoff331.70
Isology Typeequivalog
EC Number4.4.1.19
HMM Length237
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0019295: coenzyme M biosynthetic process biological_process
GO:0043817: phosphosulfolactate synthase activity molecular_function
AuthorHaft DH
Entry DateOct 1 2009 11:18AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model finds the ComA (Coenzyme M biosynthesis A) protein, phosphosulfolactate synthase, in methanogenic archaea. The ComABC pathway is one of at least two pathways to the intermediate sulfopyruvate. Coenzyme M occurs rarely and sporadically outside of the archaea, as for expoxide metabolism in Xanthobacter autotrophicus Py2, but candidate phosphosulfolactate synthases from that and other species occur fall below the cutoff and outside the scope of this model. This model deliberately is narrower in scope than PF02679.
ReferencesRN [1] RM PMID:11830598 RT Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes. RA Graham DE, Xu H, White RH RL J Biol Chem. 2002 Apr 19;277(16):13421-9. Epub 2002 Feb 5.
Genome PropertyGenProp0892: sulfopyruvate biosynthesis from phoshoenolpyruvate (HMM)