| Accession | TIGR03849 |
| Name | arch_ComA |
| Function | phosphosulfolactate synthase |
| Gene Symbol | comA |
| Trusted Cutoff | 331.90 |
| Domain Trusted Cutoff | 331.90 |
| Noise Cutoff | 331.70 |
| Domain Noise Cutoff | 331.70 |
| Isology Type | equivalog |
| EC Number | 4.4.1.19 |
| HMM Length | 237 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Gene Ontology Term | GO:0019295: coenzyme M biosynthetic process biological_process |
| | GO:0043817: phosphosulfolactate synthase activity molecular_function |
| Author | Haft DH |
| Entry Date | Oct 1 2009 11:18AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model finds the ComA (Coenzyme M biosynthesis A) protein, phosphosulfolactate synthase, in methanogenic archaea. The ComABC pathway is one of at least two pathways to the intermediate sulfopyruvate. Coenzyme M occurs rarely and sporadically outside of the archaea, as for expoxide metabolism in Xanthobacter autotrophicus Py2, but candidate phosphosulfolactate synthases from that and other species occur fall below the cutoff and outside the scope of this model. This model deliberately is narrower in scope than PF02679. |
| References | RN [1]
RM PMID:11830598
RT Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes.
RA Graham DE, Xu H, White RH
RL J Biol Chem. 2002 Apr 19;277(16):13421-9. Epub 2002 Feb 5. |
| Genome Property | GenProp0892: sulfopyruvate biosynthesis from phoshoenolpyruvate (HMM) |
