| Accession | TIGR03845 |
| Name | sulfopyru_alph |
| Function | sulfopyruvate decarboxylase, alpha subunit |
| Gene Symbol | comD |
| Trusted Cutoff | 147.95 |
| Domain Trusted Cutoff | 147.95 |
| Noise Cutoff | 100.30 |
| Domain Noise Cutoff | 100.30 |
| Isology Type | equivalog_domain |
| EC Number | 4.1.1.79 |
| HMM Length | 160 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Author | Haft DH |
| Entry Date | Sep 29 2009 1:57PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the alpha subunit, or the N-terminal region, of sulfopyruvate decarboxylase, an enzyme of coenzyme M biosynthesis. Coenzyme M is found almost exclusively in the methanogenic archaea. However, the enzyme also occurs in Roseovarius nubinhibens ISM in a degradative pathway, where the resulting sulfoacetaldehyde is desulfonated to acetyl phosphate, then converted to acetyl-CoA (see PMID:19581363). |
| References | RN [1]
RM PMID:10940029
RT Identification of the gene encoding sulfopyruvate decarboxylase, an enzyme involved in biosynthesis of coenzyme M.
RA Graupner M, Xu H, White RH
RL J Bacteriol. 2000 Sep;182(17):4862-7.
RN [2]
RM PMID:19581363
RT Bifurcated degradative pathway of 3-sulfolactate in Roseovarius nubinhibens ISM via sulfoacetaldehyde acetyltransferase and (S)-cysteate sulfolyase.
RA Denger K, Mayer J, Buhmann M, Weinitschke S, Smits TH, Cook AM
RL J Bacteriol. 2009 Sep;191(18):5648-56. Epub 2009 Jul 6. |
| Genome Property | GenProp0891: coenzyme M biosynthesis (HMM) |
