HMM Summary Page: TIGR03845

Functionsulfopyruvate decarboxylase, alpha subunit
Gene SymbolcomD
Trusted Cutoff147.95
Domain Trusted Cutoff147.95
Noise Cutoff100.30
Domain Noise Cutoff100.30
Isology Typeequivalog_domain
EC Number4.1.1.79
HMM Length160
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
AuthorHaft DH
Entry DateSep 29 2009 1:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the alpha subunit, or the N-terminal region, of sulfopyruvate decarboxylase, an enzyme of coenzyme M biosynthesis. Coenzyme M is found almost exclusively in the methanogenic archaea. However, the enzyme also occurs in Roseovarius nubinhibens ISM in a degradative pathway, where the resulting sulfoacetaldehyde is desulfonated to acetyl phosphate, then converted to acetyl-CoA (see PMID:19581363).
ReferencesRN [1] RM PMID:10940029 RT Identification of the gene encoding sulfopyruvate decarboxylase, an enzyme involved in biosynthesis of coenzyme M. RA Graupner M, Xu H, White RH RL J Bacteriol. 2000 Sep;182(17):4862-7. RN [2] RM PMID:19581363 RT Bifurcated degradative pathway of 3-sulfolactate in Roseovarius nubinhibens ISM via sulfoacetaldehyde acetyltransferase and (S)-cysteate sulfolyase. RA Denger K, Mayer J, Buhmann M, Weinitschke S, Smits TH, Cook AM RL J Bacteriol. 2009 Sep;191(18):5648-56. Epub 2009 Jul 6.
Genome PropertyGenProp0891: coenzyme M biosynthesis (HMM)