HMM Summary Page: TIGR03842

FunctionF420-dependent oxidoreductase, CPS_4043 family
Trusted Cutoff295.45
Domain Trusted Cutoff295.45
Noise Cutoff295.10
Domain Noise Cutoff295.10
Isology Typehypoth_equivalog
HMM Length329
AuthorHaft DH
Entry DateSep 25 2009 1:16PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a family of putative F420-dependent oxidoreductases, fairly closely related to 5,10-methylenetetrahydromethanopterin reductase (mer, TIGR03555), both within the bacterial luciferase-like monoxygenase (LLM) family. A fairly deep split (to about 40 % sequence identity) in the present family separates a strictly Actinobacterial clade from an alpha/beta/gamma-proteobacterial clade, in which the member is often the only apparent F420-dependent LLM family member. The specific function, and whether Actinobacterial and Proteobacterial clades differ in function, are unknown.
ReferencesRN [1] RM PMID:20675471 RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria. RA Selengut JD, Haft DH RL J Bacteriol. 2010 Nov;192(21):5788-98.
Genome PropertyGenProp0002: coenzyme F420 utilization (HMM)