HMM Summary Page: TIGR03840

Functionthiopurine S-methyltransferase, Se/Te detoxification family
Gene SymboltmpT
Trusted Cutoff223.20
Domain Trusted Cutoff223.20
Noise Cutoff189.85
Domain Noise Cutoff189.85
Isology Typeequivalog
EC Number2.1.1.67
HMM Length213
AuthorHaft DH
Entry DateSep 23 2009 1:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are thiopurine S-methyltransferase from a branch in which at least some member proteins can perform selenium methylation as a means to detoxify selenium, or perform a related detoxification of tellurium. Note that the EC number definition does not specify a particular thiopurine, but rather represents a class of activity.
ReferencesRN [1] RM PMID:9565678 RT A tellurite-resistance genetic determinant from phytopathogenic pseudomonads encodes a thiopurine methyltransferase: evidence of a widely-conserved family of methyltransferases. RA Cournoyer B, Watanabe S, Vivian A RL Biochim Biophys Acta. 1998 Apr 29;1397(2):161-8. RN [2] RM PMID:15658983 RT Freshwater selenium-methylating bacterial thiopurine methyltransferases: diversity and molecular phylogeny. RA Favre-Bonte S, Ranjard L, Colinon C, Prigent-Combaret C, Nazaret S, Cournoyer B RL Environ Microbiol. 2005 Feb;7(2):153-64.