HMM Summary Page: TIGR03838

Functionglutamyl-queuosine tRNA(Asp) synthetase
Gene SymbolgluQ
Trusted Cutoff276.70
Domain Trusted Cutoff276.70
Noise Cutoff264.10
Domain Noise Cutoff264.10
Isology Typeequivalog
EC Number6.1.1.-
HMM Length272
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0006400: tRNA modification biological_process
GO:0016876: ligase activity, forming aminoacyl-tRNA and related compounds molecular_function
AuthorHaft DH
Entry DateSep 20 2009 10:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein resembles a shortened glutamyl-tRNA ligase, but its purpose is to modify tRNA(Asp) at a queuosine position in the anticodon rather than to charge a tRNA with its cognate amino acid.
ReferencesRN [1] RM PMID:15096612 RT A truncated aminoacyl-tRNA synthetase modifies RNA. RA Salazar JC, Ambrogelly A, Crain PF, McCloskey JA, Soll D RL Proc Natl Acad Sci U S A. 2004 May 18;101(20):7536-41. RN [2] RM PMID:16164993 RT Glu-Q-tRNA(Asp) synthetase coded by the yadB gene, a new paralog of aminoacyl-tRNA synthetase that glutamylates tRNA(Asp) anticodon. RA Blaise M, Becker HD, Lapointe J, Cambillau C, Giege R, Kern D RL Biochimie. 2005 Sep-Oct;87(9-10):847-61.