HMM Summary Page: TIGR03832

Functiontyrosine 2,3-aminomutase
Gene SymbolcmdF
Trusted Cutoff501.00
Domain Trusted Cutoff501.00
Noise Cutoff492.70
Domain Noise Cutoff492.70
Isology Typeequivalog
EC Number5.4.3.6
HMM Length507
Gene Ontology TermGO:0009058: biosynthetic process biological_process
GO:0050368: tyrosine 2,3-aminomutase activity molecular_function
AuthorHaft DH
Entry DateSep 14 2009 2:39PM
Last ModifiedMay 19 2014 1:45PM
CommentMembers of this protein family are tyrosine 2,3-aminomutase. It is variable from member to member as to whether the (R)-beta-Tyr or (S)-beta-Tyr is the preferred product from L-Tyr. This enzyme tends to occur in secondary metabolite biosynthesis systems, as in the production of chondramides in Chondromyces crocatus. This class of enzyme has a prosthetic group, MIO (4-methylideneimidazol-5-one), that forms posttranslationally from an Ala-Ser-Gly motif.
ReferencesRN [1] RM PMID:19222035 RT Discovery of additional members of the tyrosine aminomutase enzyme family and the mutational analysis of CmdF. RA Krug D, Muller R RL Chembiochem. 2009 Mar 2;10(4):741-50.