HMM Summary Page: TIGR03820
Accession | TIGR03820 |
Name | lys_2_3_AblA |
Function | lysine-2,3-aminomutase |
Gene Symbol | ablA |
Trusted Cutoff | 525.40 |
Domain Trusted Cutoff | 525.40 |
Noise Cutoff | 525.15 |
Domain Noise Cutoff | 525.15 |
Isology Type | equivalog |
EC Number | 5.4.3.2 |
HMM Length | 417 |
Author | Haft DH |
Entry Date | Sep 9 2009 1:19PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This model describes lysine-2,3-aminomutase as found along with beta-lysine acetyltransferase in a two-enzyme pathway for making the compatible solute N-epsilon-acetyl-beta-lysine. This compatible solute, or osmolyte, is known to protect a number of methanogenic archaea against salt stress. The trusted cutoff distinguishes a tight clade with essentially full-length homology from additional homologs that are shorter or highly diverged in the C-terminal region. All members of this family have the radical SAM motif CXXXCXXC, while some but not all have a second copy of the motif in the C-terminal region. |
References | RN [1] RM PMID:14532061 RT Lysine-2,3-aminomutase and beta-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of Nepsilon-acetyl-beta-lysine and growth at high salinity. RA Pfluger K, Baumann S, Gottschalk G, Lin W, Santos H, Muller V RL Appl Environ Microbiol. 2003 Oct;69(10):6047-55. RN [2] RM PMID:14532061 RT Lysine-2,3-aminomutase and beta-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of Nepsilon-acetyl-beta-lysine and growth at high salinity. RA Pfluger K, Baumann S, Gottschalk G, Lin W, Santos H, Muller V RL Appl Environ Microbiol. 2003 Oct;69(10):6047-55. |
Genome Property | GenProp0878: N(epsilon)-acetyl-beta-lysine biosynthesis (HMM) |