HMM Summary Page: TIGR03804

Functionparallel beta-helix repeat
Trusted Cutoff19.45
Domain Trusted Cutoff19.45
Noise Cutoff15.60
Domain Noise Cutoff15.60
Isology Typerepeat
HMM Length44
AuthorHaft DH
Entry DateAug 13 2009 3:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a tandem pair of an approximately 22-amino acid (each) repeat homologous to the beta-strand repeats that stack in a right-handed parallel beta-helix in the periplasmic C-5 mannuronan epimerase, AlgA, of Pseudomonas aeruginosa. A homology domain consisting of a longer tandem array of these repeats is described in the SMART database as CASH (SM00722), and is found in many carbohydrate-binding proteins and sugar hydrolases. A single repeat is represented by SM00710. This TIGRFAMs model represents a flavor of the parallel beta-helix-forming repeat based on prokaryotic sequences only in its seed alignment, although it also finds many eukaryotic sequences.
ReferencesRN [1] RM PMID:11852237 RT CASH--a beta-helix domain widespread among carbohydrate-binding proteins. RA Ciccarelli FD, Copley RR, Doerks T, Russell RB, Bork P RL Trends Biochem Sci. 2002 Feb;27(2):59-62. DR SMART; SM00722 DR SMART; SM00710