| Accession | TIGR03798 |
| Name | ocin_TIGR03798 |
| Function | nif11-like leader peptide domain |
| Trusted Cutoff | 32.30 |
| Domain Trusted Cutoff | 32.30 |
| Noise Cutoff | 29.70 |
| Domain Noise Cutoff | 29.70 |
| Isology Type | subfamily |
| HMM Length | 68 |
| Author | Haft DH |
| Entry Date | Jul 28 2009 1:38PM |
| Last Modified | Aug 16 2012 4:15PM |
| Comment | This model describes a conserved, fairly long (about 65 residue) leader peptide region for a family of putative ribosomal natural products (RNP) of small size. Members of the seed alignment (most sequences scoring better than 54 bits to the HMMER 2 model) tend to have the Gly-Gly motif as the last two residues of the matched region. This is a cleavage site for a combination processing/export ABC transporter with a peptidase domain. Members include the prochlorosins, lantipeptides from Prochlorococcus. |
| References | RN [1]
RM PMID:20500830
RT Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family.
RA Haft DH, Basu MK, Mitchell DA
RL BMC Biol. 2010 May 25;8:70.
RN [2]
RM PMID:22574919
RT Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria.
RA Tang W, van der Donk WA
RL Biochemistry. 2012 May 29;51(21):4271-9. Epub 2012 May 17. |
| Genome Property | GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM) |
| | GenProp0861: bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group (HMM) |
