HMM Summary Page: TIGR03788

Functionmarine proteobacterial sortase target protein
Trusted Cutoff551.65
Domain Trusted Cutoff551.65
Noise Cutoff550.25
Domain Noise Cutoff550.25
Isology Typeequivalog
HMM Length629
AuthorHaft DH
Entry DateJun 23 2009 1:48PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are restricted to the Proteobacteria. Each contains a C-terminal sortase-recognition motif, transmembrane domain, and basic residues cluster at the the C-terminus, and is encoded adjacent to a sortase gene. This protein is frequently the only sortase target in its genome, which is as unusual its occurrence in Gram-negative rather than Gram-positive genomes. Many bacteria with this system are marine. In addition to the LPXTG signal, members carry a vault protein inter-alpha-trypsin inhibitor domain (PF08487) and a von Willebrand factor type A domain (PF00092).
ReferencesRN [1] RM PMID:15102780 RT A comparative genome analysis identifies distinct sorting pathways in gram-positive bacteria. RA Comfort D, Clubb RT RL Infect Immun. 2004 May;72(5):2710-22.
Genome PropertyGenProp0859: protein sorting system, proteobacterial dedicated sortase type (HMM)