HMM Summary Page: TIGR03784

Functionsortase, marine proteobacterial type
Trusted Cutoff158.25
Domain Trusted Cutoff158.25
Noise Cutoff136.95
Domain Noise Cutoff136.95
Isology Typeequivalog
HMM Length174
AuthorHaft DH
Entry DateJun 23 2009 11:55AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are sortase enzymes, cysteine transpeptidases involved in protein sorting activities. Members of this family tend to be found in proteobacteria, rather than in Gram-positive bacteria where sortases attach proteins to the Gram-positive cell wall or participate in pilin cross-linking. Many species with this sortase appear to contain a signal target sequence, a protein with a Vault protein inter-alpha-trypsin domain (PF08487) and a von Willebrand factor type A domain (PF00092), encoded by an adjacent gene. These sortases are designated subfamily 6 according to Comfort and Clubb (2004).
ReferencesRN [1] RM PMID:15102780 RT A comparative genome analysis identifies distinct sorting pathways in gram-positive bacteria. RA Comfort D, Clubb RT RL Infect Immun. 2004 May;72(5):2710-22.
Genome PropertyGenProp0859: protein sorting system, proteobacterial dedicated sortase type (HMM)