HMM Summary Page: TIGR03778

FunctionVPDSG-CTERM protein sorting domain
Trusted Cutoff22.00
Domain Trusted Cutoff22.00
Noise Cutoff21.00
Domain Noise Cutoff21.00
Isology Typesubfamily_domain
HMM Length24
AuthorHaft DH
Entry DateJun 17 2009 3:18PM
Last ModifiedFeb 10 2012 12:18PM
CommentThrough in silico analysis, we previously described the PEP-CTERM/exosortase system (PMID:16930487). This model describes a PEP-CTERM-like variant C-terminal protein sorting signal, as found at the C-terminus of twenty otherwise unrelated proteins in Verrucomicrobiae bacterium DG1235. The variant motif, VPDSG, seems an intermediate between the VPEP motif (TIGR02595) of typical exosortase systems and the classical LPXTG of sortase in Gram-positive bacteria.
ReferencesRN [1] RM PMID:22037399 RT Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification. RA Haft DH, Payne SH, Selengut JD RL J Bacteriol. 2012 Jan;194(1):36-48. Epub 2011 Oct 28.
Genome PropertyGenProp0985: protein sorting system, VPDSG-CTERM/exosortase C (HMM)