HMM Summary Page: TIGR03726

Functionputative cross-wall-targeting lipoprotein signal
Trusted Cutoff20.85
Domain Trusted Cutoff20.85
Noise Cutoff17.70
Domain Noise Cutoff17.70
Isology Typeequivalog_domain
HMM Length34
AuthorHaft DH
Entry DateMar 28 2009 4:49PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe YSIRK signal domain targets proteins to the cross-wall, or septum, of dividing Gram-positive bacterial. Lipoprotein signal motifs direct a characteristic N-terminal cleavage and lipid modification for membrane anchoring. This Streptococcal-only signal peptide variant appears to be a hybrid between the two, likely directing protein targeting of nascent surface lipoproteins to the cross-wall. Nearly all members of this family have the characteristic LPXTG cell wall anchor signal at the C-terminus.