HMM Summary Page: TIGR03724

FunctionKae1-associated kinase Bud32
Trusted Cutoff64.40
Domain Trusted Cutoff64.40
Noise Cutoff61.20
Domain Noise Cutoff61.20
Isology Typeequivalog_domain
EC Number2.7.-.-
HMM Length199
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateMar 18 2009 3:22PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the Bud32 protein associated with Kae1 (kinase-associated endopeptidase 1) in the Archaea. In many Archaeal genomes, Kae1 and Bud32 are fused. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex, an apparently ancient protein kinase-containing molecular machine.
ReferencesRN [1] RM PMID:19143597 RT The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya. RA Hecker A, Graille M, Madec E, Gadelle D, Le Cam E, van Tilbergh H, Forterre P RL Biochem Soc Trans. 2009 Feb;37(Pt 1):29-35. RN [2] RM PMID:19172740 RT Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex. RA Hecker A, Lopreiato R, Graille M, Collinet B, Forterre P, Libri D, van Tilbeurgh H RL EMBO J. 2008 Sep 3;27(17):2340-51. RN [3] RM PMID:18951093 RT Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. RA Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F RL Mol Cell. 2008 Oct 24;32(2):259-75.