| Accession | TIGR03723 |
| Name | T6A_TsaD_YgjD |
| Function | tRNA threonylcarbamoyl adenosine modification protein TsaD |
| Gene Symbol | tsaD |
| Trusted Cutoff | 296.10 |
| Domain Trusted Cutoff | 296.10 |
| Noise Cutoff | 287.85 |
| Domain Noise Cutoff | 287.85 |
| Isology Type | equivalog |
| HMM Length | 314 |
| Mainrole Category | Unknown function |
| Subrole Category | General |
| Author | Haft DH |
| Entry Date | Mar 18 2009 10:07AM |
| Last Modified | Aug 12 2012 6:56PM |
| Comment | This model represents bacterial members of a protein family that is widely distributed. In a few pathogenic species, the protein is exported in a way that may represent an exceptional secondary function. This model plus companion (archaeal) model TIGR03722 together span the prokaryotic member sequences of TIGR00329, a protein family that appears universal in life, and whose broad function is unknown. A member of TIGR03722 has been characterized as a DNA-binding protein with apurinic endopeptidase activity. In contrast, the rare characterized members of the present family show O-sialoglycoprotein endopeptidase (EC. 3.4.24.57) activity after export. These include glycoprotease (gcp) from Pasteurella haemolytica A1 and a cohemolysin from Riemerella anatipestifer (GB|AAG39646.1). The member from Staphylococcus aureus is essential and is related to cell wall dynamics and the modulation of autolysis, but members are also found in the Mycoplasmas (which lack a cell wall). A reasonable hypothesis is that virulence-related activities after export are secondary to a bacterial domain-wide unknown function. |
| References | RN [1]
RM PMID:22378793
RT Biosynthesis of Threonylcarbamoyl Adenosine (t6A), a Universal tRNA Nucleoside.
RA Deutsch C, El Yacoubi B, de Crecy-Lagard V, Iwata-Reuyl D
RL J Biol Chem. 2012 Apr 20;287(17):13666-73.
RN [2]
RM PMID:17237169
RT Conditional mutation of an essential putative glycoprotease eliminates autolysis in Staphylococcus aureus.
RA Zheng L, Yu C, Bayles K, Lasa I, Ji Y
RL J Bacteriol. 2007 Apr;189(7):2734-42.
RN [3]
RM PMID:1885539
RT Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene.
RA Abdullah KM, Lo RY, Mellors A
RL J Bacteriol. 1991 Sep;173(18):5597-603. |
| Genome Property | GenProp1060: tRNA N6-threonylcarbamoyladenosine modification (HMM) |
| | GenProp0799: bacterial core gene set, exactly 1 per genome (HMM) |
