HMM Summary Page: TIGR03722

Functionuniversal archaeal protein Kae1
Gene Symbolkae1
Trusted Cutoff430.90
Domain Trusted Cutoff430.90
Noise Cutoff426.45
Domain Noise Cutoff426.45
Isology Typeequivalog_domain
HMM Length323
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
AuthorHaft DH
Entry DateMar 17 2009 5:16PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family represents the archaeal protein Kae1. Its partner Bud32 is fused with it in about half of the known archaeal genomes. The pair, which appears universal in the archaea, corresponds to EKC/KEOPS complex in eukaryotes. A recent characterization of the member from Pyrococcus abyssi, as an iron-binding, atypical DNA-binding protein with an apurinic lyase activity, challenges the common annotation of close homologs as O-sialoglycoprotein endopeptidase. The latter annotation is based on a characterized protein from the bacterium Pasteurella haemolytica.
ReferencesRN [1] RM PMID:17766251 RT An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro. RA Hecker A, Leulliot N, Gadelle D, Graille M, Justome A, Dorlet P, Brochier C, Quevillon-Cheruel S, Le Cam E, van Tilbeurgh H, Forterre P RL Nucleic Acids Res. 2007;35(18):6042-51.