HMM Summary Page: TIGR03702

Functionlipid kinase YegS
Gene SymbolyegS
Trusted Cutoff387.45
Domain Trusted Cutoff387.45
Noise Cutoff197.50
Domain Noise Cutoff197.50
Isology Typeequivalog
EC Number2.7.1.-
HMM Length295
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0001727: lipid kinase activity molecular_function
GO:0005575: cellular_component cellular_component
GO:0008150: biological_process biological_process
AuthorHaft DH
Entry DateDec 13 2008 3:37PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are designated YegS, an apparent lipid kinase family in the Proteobacteria. Bakali, et al. report phosphatidylglycerol kinase activity for the member from Escherichia coli, but refrain from calling that activity synonymous with its biological role. Note that a broader, subfamily-type model (TIGR00147), includes this family but also multiple paralogs in some species and varied functions.
ReferencesRN [1] RM PMID:17351295 RT Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site. RA Bakali HM, Herman MD, Johnson KA, Kelly AA, Wieslander A, Hallberg BM, Nordlund P RL J Biol Chem. 2007 Jul 6;282(27):19644-52. Epub 2007 Mar 11. RN [2] RM PMID:17393457 RT Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases. RA Nichols CE, Lamb HK, Lockyer M, Charles IG, Pyne S, Hawkins AR, Stammers DK RL Proteins. 2007 Jul 1;68(1):13-25.