HMM Summary Page: TIGR03699

Functiondehypoxanthine futalosine cyclase
Gene SymbolmqnC
Trusted Cutoff428.10
Domain Trusted Cutoff428.10
Noise Cutoff397.65
Domain Noise Cutoff397.65
Isology Typeequivalog
HMM Length342
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0009234: menaquinone biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 18 2008 2:00PM
Last ModifiedFeb 14 2011 3:27PM
Commentmembers of this protein family are involved in menaquinone biosynthesis by an alternate pathway via futalosine.
ReferencesRN [1] RM PMID:18801996 RT An alternative menaquinone biosynthetic pathway operating in microorganisms. RA Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T RL Science. 2008 Sep 19;321(5896):1670-3. RN [2] RM PMID:23763543 RT In Vitro Reconstitution of the Radical S-Adenosylmethionine Enzyme MqnC Involved in the Biosynthesis of Futalosine-Derived Menaquinone. RA Cooper LE, Fedoseyenko D, Abdelwahed SH, Kim SH, Dairi T, Begley TP RL Biochemistry. 2013 Jun 27.
Genome PropertyGenProp0829: menaquinone biosynthesis via futalosine (HMM)