HMM Summary Page: TIGR03697

Functionglobal nitrogen regulator NtcA
Gene SymbolntcA
Trusted Cutoff244.95
Domain Trusted Cutoff244.95
Noise Cutoff227.45
Domain Noise Cutoff227.45
Isology Typeequivalog
HMM Length193
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003677: DNA binding molecular_function
GO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0006808: regulation of nitrogen utilization biological_process
AuthorHaft DH
Entry DateNov 14 2008 1:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family, found in the cyanobacteria, are the global nitrogen regulator NtcA. This DNA-binding transcriptional regulator is required for expressing many different ammonia-repressible genes. The consensus NtcA-binding site is G T A N(8)T A C.
ReferencesRN [1] RM PMID:8366058 RT General distribution of the nitrogen control gene ntcA in cyanobacteria. RA Frias JE, Merida A, Herrero A, Martin-Nieto J, Flores E RL J Bacteriol. 1993 Sep;175(17):5710-3. RN [2] RM PMID:18805988 RT Role of two NtcA-binding sites in the complex ntcA gene promoter of the heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120. RA Olmedo-Verd E, Valladares A, Flores E, Herrero A, Muro-Pastor AM RL J Bacteriol. 2008 Nov;190(22):7584-90.