HMM Summary Page: TIGR03693

Functionputative thiazole-containing bacteriocin maturation protein
Trusted Cutoff561.90
Domain Trusted Cutoff561.90
Noise Cutoff142.30
Domain Noise Cutoff142.30
Isology Typehypoth_equivalog
HMM Length637
Mainrole CategoryCellular processes
Subrole CategoryToxin production and resistance
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0005575: cellular_component cellular_component
GO:0030152: bacteriocin biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 8 2008 10:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are found in a three-gene operon in Bacillus anthracis and related Bacillus species, where the other two genes are clearly identified with maturation of a putative thiazole-containing bacteriocin precursor. While there is no detectable pairwise sequence similarity between members of this family and the proposed cyclodehydratases such as SagC of Streptococcus pyogenes (see family TIGR03603), both families show similarity through PSI-BLAST to ThiF, a protein involved in biosynthesis of the thiazole moiety for thiamine biosynthesis. This family, therefore, may contribute to cyclodehydratase function in heterocycle-containing bacteriocin biosyntheses. In Bacillus licheniformis ATCC 14580, the bacteriocin precursor gene is adjacent to the gene for this protein.