HMM Summary Page: TIGR03692

FunctionATP-dependent protease HslVU, peptidase subunit
Gene SymbolhslV
Trusted Cutoff157.75
Domain Trusted Cutoff157.75
Noise Cutoff94.90
Domain Noise Cutoff94.90
Isology Typeequivalog
EC Number3.4.25.2
HMM Length171
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0004176: ATP-dependent peptidase activity molecular_function
GO:0004298: threonine-type endopeptidase activity molecular_function
GO:0006508: proteolysis biological_process
GO:0009376: HslUV protease complex cellular_component
AuthorHaft DH
Entry DateNov 6 2008 2:43PM
Last ModifiedDec 12 2011 10:41PM
CommentThe ATP-dependent protease HslVU, a complex of hexameric HslU active as a protein-unfolding ATPase and dodecameric HslV, the catalytic threonine protease.
ReferencesRN [1] RM PMID:15849200 RT Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase. RA Park E, Rho YM, Koh OJ, Ahn SW, Seong IS, Song JJ, Bang O, Seol JH, Wang J, Eom SH, Chung CH RL J Biol Chem. 2005 Jun 17;280(24):22892-8. Epub 2005 Apr 22. RN [2] RM PMID:12446803 RT Eubacterial HslV and HslU subunits homologs in primordial eukaryotes. RA Couvreur B, Wattiez R, Bollen A, Falmagne P, Le Ray D, Dujardin JC RL Mol Biol Evol. 2002 Dec;19(12):2110-7.
Genome PropertyGenProp0835: ATP-dependent protease HslVU (HMM)