HMM Summary Page: TIGR03691

Functionproteasome, alpha subunit
Gene SymbolprcA
Trusted Cutoff139.05
Domain Trusted Cutoff139.05
Noise Cutoff62.65
Domain Noise Cutoff62.65
Isology Typeequivalog
EC Number3.4.25.1
HMM Length229
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0004298: threonine-type endopeptidase activity molecular_function
GO:0005839: proteasome core complex cellular_component
GO:0010498: proteasomal protein catabolic process biological_process
AuthorHaft DH
Entry DateNov 6 2008 10:20AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the alpha subunit of the 20S proteasome as found in Actinobacteria such as Mycobacterium, Rhodococcus, and Streptomyces. In most Actinobacteria (an exception is Propionibacterium acnes), the proteasome is accompanied by a system of tagging proteins for degradation with Pup.
ReferencesRN [1] RM PMID:9765579 RT The 20S proteasome of Streptomyces coelicolor. RA Nagy I, Tamura T, Vanderleyden J, Baumeister W, De Mot R RL J Bacteriol. 1998 Oct;180(20):5448-53. RN [2] RM PMID:16468985 RT Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. RA Lin G, Hu G, Tsu C, Kunes YZ, Li H, Dick L, Parsons T, Li P, Chen Z, Zwickl P, Weich N, Nathan C RL Mol Microbiol. 2006 Mar;59(5):1405-16.
Genome PropertyGenProp0834: proteasome, bacterial (HMM)