HMM Summary Page: TIGR03688

Functionproteasome accessory factor PafA2
Trusted Cutoff492.30
Domain Trusted Cutoff492.30
Noise Cutoff406.65
Domain Noise Cutoff406.65
Isology Typeequivalog
EC Number6.3.2.-
HMM Length485
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0010498: proteasomal protein catabolic process biological_process
GO:0016879: ligase activity, forming carbon-nitrogen bonds molecular_function
GO:0019941: modification-dependent protein catabolic process biological_process
AuthorHaft DH
Entry DateNov 5 2008 11:04AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family is paralogous to (and distinct from) the PafA (proteasome accessory factor) first described in Mycobacterium tuberculosis (see TIGR03686). Members of both this family and TIGR03686 itself tend to cluster with each other, with the ubiquitin analog Pup (TIGR03687) associated with targeting to the proteasome, and with proteasome subunits themselves.
ReferencesRN [1] RM PMID:17277063 RT Characterization of the proteasome accessory factor (paf) operon in Mycobacterium tuberculosis. RA Festa RA, Pearce MJ, Darwin KH RL J Bacteriol. 2007 Apr;189(8):3044-50. RN [2] RM PMID:18832610 RT Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis. RA Pearce MJ, Mintseris J, Ferreyra J, Gygi SP, Darwin KH RL Science. 2008 Oct 2.
Genome PropertyGenProp0833: proteasome-targeting modification by pupylation (HMM)