HMM Summary Page: TIGR03687

Functionubiquitin-like protein Pup
Trusted Cutoff41.45
Domain Trusted Cutoff41.45
Noise Cutoff24.80
Domain Noise Cutoff24.80
Isology Typeequivalog_domain
HMM Length33
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0010498: proteasomal protein catabolic process biological_process
GO:0019941: modification-dependent protein catabolic process biological_process
AuthorHaft DH
Entry DateNov 5 2008 10:30AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are Pup, a small protein whose ligation to target proteins steers them toward degradation. This protein family occurs in a number of bacteria, especially Actinobacteria such as Mycobacterium tuberculosis, that possess an archeal-type proteasome. All members of this protein family known during model construction end with the C-terminal motif [FY][VI]QKGG[QE]. Ligation is thought to occur between the C-terminal COOH of Pup and an epsilon-amino group of a Lys on the target protein. The N-terminal half of this protein is poorly conserved and not represented in the seed alignment.
ReferencesRN [1] RM PMID:18832610 RT Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis. RA Pearce MJ, Mintseris J, Ferreyra J, Gygi SP, Darwin KH RL Science. 2008 Oct 2.
Genome PropertyGenProp0833: proteasome-targeting modification by pupylation (HMM)