HMM Summary Page: TIGR03674

Functionflap structure-specific endonuclease
Gene Symbolfen
Trusted Cutoff351.95
Domain Trusted Cutoff351.95
Noise Cutoff351.80
Domain Noise Cutoff351.80
Isology Typeequivalog
EC Number3.1.-.-
HMM Length338
AuthorSelengut J
Entry DateOct 22 2008 12:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentEndonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Has 5'-endo-/exonuclease and 5'-pseudo-Y-endonuclease activities. Cleaves the junction between single and double-stranded regions of flap DNA
ReferencesRN [1] RM PMID:12147694 RT Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshii. RA Matsui E, Musti KV, Abe J, Yamasaki K, Matsui I, Harata K RL J Biol Chem. 2002 Oct 4;277(40):37840-7. Epub 2002 Jul 29.
Genome PropertyGenProp0831: archaeal core gene set, exactly 1 per genome (HMM)