HMM Summary Page: TIGR03668

FunctionPPOX class probable F420-dependent enzyme, Rv0121 family
Trusted Cutoff119.15
Domain Trusted Cutoff119.15
Noise Cutoff77.50
Domain Noise Cutoff77.50
Isology Typehypoth_equivalog
HMM Length141
AuthorHaft DH
Entry DateOct 20 2008 8:11AM
Last ModifiedFeb 14 2011 3:27PM
CommentA Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN.
ReferencesRN [1] RM PMID:20675471 RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria. RA Selengut JD, Haft DH RL J Bacteriol. 2010 Nov;192(21):5788-98. RN [2] RM PMID:16930487 RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic. RA Haft DH, Paulsen IT, Ward N, Selengut JD RL BMC Biol. 2006 Aug 24;4:29.
Genome PropertyGenProp0002: coenzyme F420 utilization (HMM)